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darifenacin decreases outcomes of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Caution/Check. Helps prevent conversion of codeine to its active metabolite morphine.

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artemether/lumefantrine will improve the level or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Keep an eye on.

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Reserve concomitant prescribing of such medicines in clients for whom other remedy solutions are inadequate. Restrict dosages and durations for the minimum essential. Observe intently for signs of respiratory melancholy and sedation.

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